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Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, Ulleråker, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, Ulleråker, University Hospital.
2006 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 74, no 5, 339-346 p.Article in journal (Refereed) Published
Abstract [en]

Patients with schizophrenia have in different studies shown reduced niacin sensitivity and lower electrodermal activity (EDA) after auditory stimulation. Peripheral mediation of prostaglandins may have a physiological role in both responses. This motivates study of both niacin response and electrodermal responding in the same patients with schizophrenia. Thirty patients with schizophrenia and 17 controls were investigated with EDA and thereafter given 200 mg niacin orally with continuous assessment of skin temperature. The patients showed a delayed temperature increase after niacin ingestion (P = 0.002) and a higher frequency of electrodermal non-responding (P < 0.05). Response/non-response for niacin correlated with EDA response/non-response in the patient group (P = 0.009). The niacin test revealed a slower vasodilation reaction in the patients. The association between response patterns for the niacin test and EDA suggests that a common aberration in skin physiology may be of importance for both reactions in schizophrenia.

Place, publisher, year, edition, pages
2006. Vol. 74, no 5, 339-346 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-103527DOI: 10.1016/j.plefa.2006.02.002ISI: 000238169700008PubMedID: 16600583OAI: oai:DiVA.org:uu-103527DiVA: diva2:218399
Available from: 2009-05-19 Created: 2009-05-19 Last updated: 2017-12-13Bibliographically approved

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