Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly
2009 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 32, no 4, 733-735 p.Article in journal (Refereed) Published
OBJECTIVE: We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS: Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESULTS: In analyses adjusted for multiple CVD risk factors, we observed inverse associations of RBP4 with carotid artery intima-media (beta -0.39, 95% CI -0.55 to -0.22) and plaque (beta -0.33, 95% CI -0.60 to -0.05) echogenicity (gray scale median). CONCLUSIONS: Circulating RBP4 concentrations were inversely associated with intima-media and plaque echogenicity in carotid arteries. These findings imply that RBP4 could be involved in the development of atherosclerosis.
Place, publisher, year, edition, pages
2009. Vol. 32, no 4, 733-735 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-103670DOI: 10.2337/dc08-1656ISI: 000264819800040PubMedID: 19114616OAI: oai:DiVA.org:uu-103670DiVA: diva2:218611