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Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.ORCID iD: 0000-0003-2256-6972
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2009 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 32, no 4, 733-735 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS: Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESULTS: In analyses adjusted for multiple CVD risk factors, we observed inverse associations of RBP4 with carotid artery intima-media (beta -0.39, 95% CI -0.55 to -0.22) and plaque (beta -0.33, 95% CI -0.60 to -0.05) echogenicity (gray scale median). CONCLUSIONS: Circulating RBP4 concentrations were inversely associated with intima-media and plaque echogenicity in carotid arteries. These findings imply that RBP4 could be involved in the development of atherosclerosis.

Place, publisher, year, edition, pages
2009. Vol. 32, no 4, 733-735 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-103670DOI: 10.2337/dc08-1656ISI: 000264819800040PubMedID: 19114616OAI: oai:DiVA.org:uu-103670DiVA: diva2:218611
Available from: 2009-05-20 Created: 2009-05-20 Last updated: 2016-01-25Bibliographically approved

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Ingelsson, Erik

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