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Hyperaemic blood-flow velocities in systole and diastole relate to coronary risk in divergent ways
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (PIVUS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (PIVUS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (PIVUS)
2008 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 28, no 3, 189-95 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A recent study suggested blood-flow velocity in diastole during reactive hyperaemia as a major driver of flow-mediated vasodilation (FMD) of the brachial artery, also being related to cardiovascular risk factors. The present study aimed to investigate the relative importance of hyperaemic systolic and diastolic blood-flow velocity in the forearm regarding both FMD and cardiovascular risk factors. METHODS: In the Prospective Investigation of the Vasculature in Uppsala Seniors study, conducted in 1016 subjects aged 70 years, FMD, systolic and diastolic blood hyperaemic flow velocities in the brachial artery were evaluated by ultrasound. RESULTS: Hyperaemic blood-flow velocity both in systole and diastole were related to FMD (r = 0.14-0.19, P<0.0001). However, while hyperaemic systolic blood-flow velocity was related to coronary risk (Framingham risk score) in a positive way (r = 0.08, P = 0.013), diastolic blood-flow velocity was inversely related to coronary risk (r = -0.08, P = 0.016). Therefore, the systolic to diastolic hyperaemic blood-flow velocity ratio was more powerful related to coronary risk (r = 0.23, P = 0.0001). In a multiple regression model, both FMD and the systolic to diastolic hyperaemic blood-flow velocity ratio were independent predictors of coronary risk (P = 0.018 and P = 0.0001). CONCLUSION: As hyperaemic blood-flow velocities in systole and diastole in the brachial artery were related to coronary risk in divergent ways, the ratio thereof is a promising index of vascular function providing independent information regarding coronary risk when compared with FMD.

Place, publisher, year, edition, pages
2008. Vol. 28, no 3, 189-95 p.
Keyword [en]
brachial blood velocity systole diastole hyperemia cardiovascular risk
National Category
Medical and Health Sciences
Research subject
Medicine; Internal Medicine; Cardiology
Identifiers
URN: urn:nbn:se:uu:diva-103741DOI: 10.1111/j.1475-097X.2008.00797.xISI: 000254807900008PubMedID: 18355345OAI: oai:DiVA.org:uu-103741DiVA: diva2:218670
Projects
PIVUS
Available from: 2009-05-20 Created: 2009-05-20 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Hyperemic Brachial Artery Blood Flow Velocity
Open this publication in new window or tab >>Hyperemic Brachial Artery Blood Flow Velocity
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis aims to evaluate the blood flow velocity in the Brachial artery during reactive hyperemia. Primarily to appraise the information it might contain regarding cardiovascular function and cardiovascular risk.

Ultrasonographic doppler measurements of the Brachial artery were made on the 1016 men and women aged 70 included in the prospective investigation of the vasculature in Uppsala seniors (PIVUS) study. Analysis of the blood flow velocity in the forearm was made in comparison to established methods of estimating endothelial function, clinical markers of cardiovascular risk, the Framingham risk score and global atherosclerosis determined by whole body magnetic resonance angiography.

Systolic blood flow velocity was positively related to cardiovascular risk whereas the diastolic velocity was inversely correlated. However, the systolic to diastolic blood flow velocity (SDFV) ratio was more closely associated with cardiovascular risk than its components apart.

Ultrasonographic markers of Carotid atherosclerosis were related to the SDFV ratio. Concentric left ventricular remodeling and left ventricular mass index were also associated with the SDFV ratio, but not to its numerator or denominator separately. A similar pattern was found when assessing SDFV ratio in relation to global atherosclerosis, as well as to established markers of arterial compliance and vasodilation.

In conclusion, during reactive hyperemia of the Brachial artery, the systolic to diastolic blood flow velocity ratio appears to contain information of additional value than its components separately, independently of established cardiovascular risk factors. Possibly, the SDFV ratio could offer a promising means to estimate cardiovascular risk in aging populations.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 79 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 620
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-132918 (URN)978-91-554-7942-8 (ISBN)
Public defence
2010-12-15, Enghoffsalen, Ingång 50, Akademiska Sjukhuset, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Projects
PIVUS
Available from: 2010-11-24 Created: 2010-10-28 Last updated: 2011-01-13Bibliographically approved

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Järhult, Susann J.

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