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Action of progesterone and progesterone metabolites in menstrual-cycle-related disorders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
2008 (English)In: Headache, ISSN 0017-8748, E-ISSN 1526-4610, Vol. 48, no Supp 2, S90-S98 p.Article in journal (Refereed) Published
Abstract [en]

Progesterone and progesterone metabolites are important modulators of central nervous system function through their interactions with the γ-aminobutyric acid (GABA)A receptor. GABA, neurosteroids, and other modulators of GABAA, such as benzodiazepines, barbiturates, and alcohol, typically inhibit neuronal excitability. The resulting anxiolytic, anticonvulsant, sedative, and anesthetic effects are involved in mood, response to stress, and cognition.

The impact of neurosteroids has been demonstrated in women with premenstrual dysphoric disorder: onset of negative mood symptoms has been correlated with peak progesterone levels, and symptoms intensified with progesterone withdrawal in the late luteal phase of the menstrual cycle. These symptoms were not present during anovulatory cycles without the corpus luteum, the primary source of progesterone and metabolites.

The focus of this article is the paradox of why high levels of progesterone and neurosteroids, which typically are associated with anxiolytic activity, instead induce irritability, anxiety, and mood fluctuations in women with premenstrual dysphoric disorder.

Place, publisher, year, edition, pages
2008. Vol. 48, no Supp 2, S90-S98 p.
Keyword [en]
premenstrual dysphoric disorder, γ-aminobutyric acid receptor, allopregnanolone
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-103783DOI: 10.1111/j.1526-4610.2008.01201.xISI: 000257551400003OAI: oai:DiVA.org:uu-103783DiVA: diva2:218701
Conference Information: Symposium on Neuroactive Steroid Effects on the CNS - Cognitive Function and Migraines held in Conjunction with the 49th Annual Scientific Meeting of the American-Headache-Society Chicago, IL, JUN 09, 2007Available from: 2009-05-20 Created: 2009-05-20 Last updated: 2011-03-21Bibliographically approved

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