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TGF-beta Targets PAX3 to Control Melanocyte Differentiation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2008 (English)In: Developmental Cell, ISSN 1534-5807, E-ISSN 1878-1551, Vol. 15, no 6, 797-799 p.Article in journal (Other academic) Published
Abstract [en]

In the absence of UV radiation, keratinocytes secrete TGF-beta which blocks melanocyte differentiation. Yang et al. (2008), in a recent issue of Molecular Cell, show that TGF-beta induces Smad signaling in melanocytes to repress PAX3, which encodes a transcription factor crucial for melanocyte differentiation. In the presence of UV radiation, a Jnk/AP-1 pathway represses TGF-beta, which together with a UV-induced p53 pathway promotes melanocyte differentiation.

Place, publisher, year, edition, pages
2008. Vol. 15, no 6, 797-799 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-103808DOI: 10.1016/j.devcel.2008.11.009PubMedID: 19081068OAI: oai:DiVA.org:uu-103808DiVA: diva2:218734
Available from: 2009-05-20 Created: 2009-05-20 Last updated: 2017-12-13Bibliographically approved

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