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Proteomic identification of p53-dependent protein phosphorylation
Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Department of Oncology-Pathology, Karolinska Biomic Center, Karolinska Institutet, Stockholm, Sweden.
Department of Surgery, University of Schleswig-Holstein, Lu¨beck, Germany.
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2008 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 27, no 35, 4854-4859 p.Article in journal (Refereed) Published
Abstract [en]

The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modifications may contribute to p53-mediated tumor suppression.

Place, publisher, year, edition, pages
2008. Vol. 27, no 35, 4854-4859 p.
Keyword [en]
p53, proteomics, phosphorylation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-103891DOI: 10.1038/onc.2008.124ISI: 000258445100010OAI: oai:DiVA.org:uu-103891DiVA: diva2:218945
Available from: 2009-05-25 Created: 2009-05-25 Last updated: 2017-12-13Bibliographically approved

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