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Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Systemic Autoimmunity)
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2009 (English)In: Immunology, ISSN 0019-2805, E-ISSN 1365-2567, Vol. 126, no 1, 140-6 p.Article in journal (Refereed) Published
Abstract [en]

Natural killer (NK) cells belong to the innate immune system but can also affect adaptive immune reactions. This immune regulatory function is often ascribed to the CD56(bright) subpopulation of NK cells that is prevalent in secondary lymphoid tissues and has potent cytokine-producing ability. The NK cells have been described as affecting autoimmune disease and stimulating B-cell production of antibodies, but their role in systemic lupus erythematosus (SLE) pathology has not been extensively studied. We have studied NK cells in SLE, a B-cell-driven systemic autoimmune disease, and phenotypically characterized peripheral blood NK cells in comparison to NK cells from patients with immunoglobulin A nephritis, rheumatoid arthritis and healthy individuals. We have found an increased proportion of CD56(bright) NK cells in SLE, regardless of disease activity. We detected a somewhat increased expression of the activating receptor NKp46/CD335 on NK cells from SLE patients, although neither the percentage of NK cells of all lymphocytes nor the expression of other NK receptors analysed (LIR-1/CD85j, CD94, NKG2C/CD159c, NKG2D/CD314, NKp30/CD337, NKp44/CD336, CD69) differed between patient groups. We show that type I interferon, a proinflammatory cytokine known to be abundant in SLE, can cause increases of CD56(bright) NK cells in vitro. We confirmed that serum levels of interferon-alpha were increased in active, but not in inactive, disease in the SLE patient group. In conclusion, we found an increased proportion of CD56(bright) NK cells in the blood of SLE patients, although it remains to be examined whether and how this relates to the disease process.

Place, publisher, year, edition, pages
2009. Vol. 126, no 1, 140-6 p.
Keyword [en]
NK cells, type I IFN, interferon
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104052DOI: 10.1111/j.1365-2567.2008.02887.xISI: 000261528300016PubMedID: 18564343OAI: oai:DiVA.org:uu-104052DiVA: diva2:219287
Available from: 2009-05-27 Created: 2009-05-27 Last updated: 2012-02-16Bibliographically approved

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Eloranta, Maija-Leena

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