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Neuroprotective effects of melanocortins in CNS injury
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
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2007 (English)In: Current pharmaceutical design, ISSN 1381-6128, E-ISSN 1873-4286, Vol. 13, no 19, 1929-1941 p.Article, review/survey (Refereed) Published
Abstract [en]

New compounds having affinity to various melanocortin receptors have recently been identified as possible neuroprotective agents. This review is focused on the role of neuroprotective effects of melanocortins in CNS injury and repair mechanisms. Using selective non-peptidic compounds with varying affinity to melanocortin receptors, our laboratory has shown their anti-edematous effects in the spinal cord injury. This effect of the compounds is related with their ability to attenuate blood-spinal cord barrier permeability. The functional significance and possible therapeutic strategies of these compounds in CNS injury are discussed.

Place, publisher, year, edition, pages
2007. Vol. 13, no 19, 1929-1941 p.
Keyword [en]
Melanocortins, spinal cord injury, edema formation, cell injury, melanocortins receptor, blood-spinal cord barrier
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104130DOI: 10.2174/138161207781039797ISI: 000247898500001PubMedID: 17627526OAI: oai:DiVA.org:uu-104130DiVA: diva2:219368
Available from: 2009-05-27 Created: 2009-05-27 Last updated: 2017-12-13Bibliographically approved

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Sharma, Hari ShankerWiklund, Lars

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Anaesthesiology and Intensive CareDepartment of Medicinal Chemistry
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