uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Renal dysfunction as a risk factor for mortality and cardiovascular disease in renal transplantation: experience from the Assessment of Lescol in Renal Transplantation trial
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Njurmedicin, The ALERT trial)
(The ALERT Trial)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Njurmedicin, The ALERT Trial)
(The ALERT Trial)
Show others and affiliations
2005 (English)In: Transplantation, ISSN 0041-1337, E-ISSN 1534-6080, Vol. 79, no 9, 1160-1163 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Renal-transplant recipients have shortened life expectancy primarily because of premature cardiovascular disease. Traditional and nontraditional risk factors for cardiovascular disease are prevalent in renal patients. In renal-transplant recipients, immunosuppressive therapy can be nephrotoxic and aggravate cardiovascular disease risk factors. Renal dysfunction has been established as a risk factor for cardiovascular disease and mortality in different populations. We evaluated the effects of baseline renal-transplant function on mortality and cardiovascular and renal endpoints in 1,052 placebo-treated patients of the Assessment of Lescol in Renal Transplantation trial. METHODS: All renal-transplant recipients were on cyclosporine-based immunosuppressive therapy. Follow-up was 5 to 6 years, and endpoints included cardiac death, noncardiovascular death, all-cause mortality, major adverse cardiac event (MACE), stroke, nonfatal myocardial infarction, and graft loss. RESULTS: Baseline serum creatinine was strongly and independently associated with increased cardiac, noncardiovascular, and all-cause mortality, as well as MACE and graft loss. Serum creatinine was not a risk factor for stroke or nonfatal myocardial infarction. CONCLUSIONS: Elevated baseline serum creatinine in renal-transplant recipients is a strong and independent risk factor for all-cause, noncardiovascular and cardiac mortality, MACE, and graft loss.

Place, publisher, year, edition, pages
Lippincott, Williams and Wilkins , 2005. Vol. 79, no 9, 1160-1163 p.
Keyword [en]
Renal transplant function, Risk factor, Mortality, Cardiovascular disease
National Category
Urology and Nephrology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:uu:diva-104290PubMedID: 15880062OAI: oai:DiVA.org:uu-104290DiVA: diva2:219610
Available from: 2009-05-28 Created: 2009-05-28 Last updated: 2010-08-13Bibliographically approved

Open Access in DiVA

No full text

PubMed

Authority records BETA

Fellström, BengtSoveri, Inga

Search in DiVA

By author/editor
Fellström, BengtSoveri, Inga
By organisation
Department of Medical Sciences
In the same journal
Transplantation
Urology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 452 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf