Microwave-assisted, Mo(CO)(6)-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up
2008 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 49, no 39, 5625-5628 p.Article in journal (Refereed) Published
Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO)(6) as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully. (C) 2008 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
2008. Vol. 49, no 39, 5625-5628 p.
carbonylation, microwave, palladium, aryl chloride, scale-up
IdentifiersURN: urn:nbn:se:uu:diva-104304DOI: 10.1016/j.tetlet.2008.07.053ISI: 000259309700018ISBN: 0040-4039OAI: oai:DiVA.org:uu-104304DiVA: diva2:219616