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Nandrolone decanoate administration dose-dependently affects the density of kappa opioid peptide receptors in the rat brain determined by autoradiography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2009 (English)In: Neuropeptides, ISSN 0143-4179, E-ISSN 1532-2785, Vol. 43, no 2, 105-111 p.Article in journal (Refereed) Published
Abstract [en]

The kappa opioid receptor ligand [(3)H]CI-977 was used to autoradiographically determine the density of kappa opioid receptors in the male rat brain following chronic treatment with the anabolic androgenic steroid nandrolone decanoate at two different doses. As compared to controls, significantly lower densities of the kappa opioid receptor were encountered after two weeks of high dose nandrolone decanoate (15 mg/kg) in the nucleus accumbens shell (16%), lateral hypothalamic area (36%), ventromedial hypothalamic nucleus (37%), dorsomedial hypothalamic nucleus (49%), central amygdaloid nucleus, capsular part (28%), lateral globus pallidus (35%) and in the stria terminalis (24%). Furthermore, an up-regulation of the receptor level was observed in the caudate putamen (18%) and in the dorsal endopiriform nucleus (23%). These alterations in the kappa opioid receptor expression are possibly attributed to a previously observed pronounced impact of nandrolone decanoate on the dynorphinergic system and could also include involvement of the dopaminergic reward system.

Place, publisher, year, edition, pages
2009. Vol. 43, no 2, 105-111 p.
Keyword [en]
Anabolic androgenic steroids (AAS), Autoradiography, Kappa opioid peptide receptor (KOP receptor), Rat, Brain
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104435DOI: 10.1016/j.npep.2008.12.005ISI: 000265520700006PubMedID: 19201466OAI: oai:DiVA.org:uu-104435DiVA: diva2:219825
Available from: 2009-05-28 Created: 2009-05-28 Last updated: 2017-12-13Bibliographically approved
In thesis
1. The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence
Open this publication in new window or tab >>The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. Previous studies have shown nandrolone-induced effects in male rats on peptide levels within the Substance P (SP) system and the dynorphinergic system; these effects may be linked to some of the reported behavior alterations. The studies presented in this thesis aimed to investigate the mechanisms underlying these peptide alterations and also to further investigate neuropeptidergic effects attributed to nandrolone administration. The results display significant effects on the enzymatic conversion of SP and Dynorphin A into their bioactive metabolites SP(1-7) and Leu-enkephalin-Arg6, respectively, as a result of nandrolone treatment. More profound investigations on the dynorphinergic system displayed effects on the kappa opioid receptor density in various brain regions. There was also a significant increase in the expression of the gene transcript of prodynorphin in the hippocampus, a brain region associated with cognitive processes. In addition, impaired spatial learning and memory in the Morris water maze task following nandrolone administration was encountered. The results provide further understanding regarding neuropeptidergic mechanisms underlying AAS-induced behavioral effects.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 59 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 1651-6192 ; 103
Keyword
Anabolic androgenic steroids, Nandrolone decanoate, Substance P, Dynorphin A, KOP receptor, Prodynorphin, Radioimmunoassay, Autoradiography, Morris water maze, PCR, Central nervous system
National Category
Pharmacology and Toxicology
Research subject
Biological Research on Drug Dependence
Identifiers
urn:nbn:se:uu:diva-107483 (URN)978-91-554-7587-1 (ISBN)
Public defence
2009-09-25, B42, BMC, Husargatan 3, Uppsala, 13:15 (English)
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Supervisors
Available from: 2009-09-03 Created: 2009-08-12 Last updated: 2011-05-05Bibliographically approved

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Magnusson, KristinaBergström, LenaNyberg, FredHallberg, Mathias

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