Will the universal definition of myocardial infarction criteria result in an overdiagnosis of myocardial infarction?
2009 (English)In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 103, no 5, 588-591 p.Article in journal (Refereed) Published
The Universal Definition of Myocardial Infarction (acute myocardial infarction [AMI]) requires detection of increasing or decreasing cardiac biomarkers (preferably cardiac troponin) with >or=1 value >99(th) percentile, together with either clinical symptoms, new ischemic electrocardiographic changes, or typical imaging findings indicative of myocardial necrosis as diagnostic criteria for AMI. However, a small cardiac troponin elevation together with ST-T segment abnormalities may also occur in clinically stable populations. Accordingly, 0.6% of elderly subjects from a community sample (PIVUS Study) and 6.7% of patients stabilized after an acute coronary syndrome (FRISC II Study) would have been labeled AMI following the Universal Definition of AMI when diagnostic classification had been based on a single cardiac troponin I result. In conclusion, our results emphasized the importance of a significant change in cardiac troponin to avoid misdiagnosis of AMI.
Place, publisher, year, edition, pages
Elsevier , 2009. Vol. 103, no 5, 588-591 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-104460DOI: 10.1016/j.amjcard.2008.11.007ISI: 000263986500003PubMedID: 19231317OAI: oai:DiVA.org:uu-104460DiVA: diva2:219841