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Automated, high-resolution cellular retention and uptake studies in vitro
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2006 (English)In: Applied Radiation and Isotopes, ISSN 0969-8043, E-ISSN 1872-9800, Vol. 64, no 8, 901-905 p.Article in journal (Refereed) Published
Abstract [en]

This report describes an automated method for the measurements of cellular retention and uptake of radiolabeled proteins interacting with cell-surface receptors on intact cancer cells. A complete uptake and retention measurement was performed in one cell dish using a rotating radioimmunoassay (RIA) principle. Compared to common manual measurements, rotating RIA saved both labor time and reagents and provided real-time binding traces with superior time-resolution. The rotating RIA retention profiles for different interactions agreed with retention times reported in the literature.

Place, publisher, year, edition, pages
2006. Vol. 64, no 8, 901-905 p.
Keyword [en]
Cellular uptake, Cellular retention, Protein interactions, Kinetics
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-104522DOI: 10.1016/j.apradiso.2006.03.002ISI: 000238809400008PubMedID: 16618544OAI: oai:DiVA.org:uu-104522DiVA: diva2:219903
Available from: 2009-05-28 Created: 2009-05-28 Last updated: 2016-08-24Bibliographically approved

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Andersson, Karl

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