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Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine
Virco UK, Ltd, Cambridge.
2001 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 45, no 7, 2144-2146 p.Article in journal (Refereed) Published
Abstract [en]

We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved in an ATP-dependent resistance mechanism analogous to pyrophosphorolysis, whereas the mechanism for RT with the Q151M or V75T mutation appears to be independent of added ATP for reducing binding to d4T-triphosphate.

Place, publisher, year, edition, pages
2001. Vol. 45, no 7, 2144-2146 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-104564DOI: 10.1128/AAC.45.7.2144-2146.2001ISI: 000169416800036PubMedID: 11408240OAI: oai:DiVA.org:uu-104564DiVA: diva2:219947
Available from: 2009-05-28 Created: 2009-05-28 Last updated: 2013-10-24Bibliographically approved

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Lennerstrand, Johan

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