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EGFR-family expression and implications for targeted radionuclide therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2008 (English)In: Targeted Radionuclide Therapy: Biological Aspects, New York: Springer , 2008, 25-58 p.Chapter in book (Other academic)
Abstract [en]

Summary High expression in the primary tumor of receptors in the EGFR-family is most often also accompanied by a similar high expression in corresponding metastases. This makes these receptors interesting as putative targets for targeted radionuclide therapy of metastases and disseminated tumor cells. The expression of all four family members, EGFR, HER2, HER3 and HER4 is reviewed in this chapter. Studies on breast, urinary bladder, colorectal, prostate, head and neck, esophageal and glioma tumors are described and possible strategies for targeted radionuclide therapy are discussed. Quantification of receptor expression and the possible influence of genomic stability on the expression are also discussed.

Place, publisher, year, edition, pages
New York: Springer , 2008. 25-58 p.
Keyword [en]
Radionuclide, Tumor, Cancer, Therapy, Radiation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104658ISBN: 978-1-4020-8695-3OAI: oai:DiVA.org:uu-104658DiVA: diva2:220036
Editors: Torgny Stigbrand, Jörgen Carlsson, Gregory P. AdamsAvailable from: 2009-05-29 Created: 2009-05-29 Last updated: 2009-06-22Bibliographically approved

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