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Effects of low dose-rate radiation on cellular survival
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2008 (English)In: Targeted Radionuclide Tumor Therapy: Biological Aspects, New York: Springer , 2008, 295-310 p.Chapter in book (Other (popular science, discussion, etc.))
Abstract [en]

The experience of external radiotherapy can only to a limited extent be used to understand therapeutic effects of radionuclide therapy. A major difference is that the dose-rate at radionuclide therapy is at least two orders of magnitude lower. Part of this chapter deals with estimates of the necessary dose-rate and exposure time in combination in order to deliver therapeutic effects to tumour cells. It is proposed that combinations of about 0.1–0.2 Gy/h for several days or about 1 Gy/h for at least 1 day is necessary. Such dose-rates can be achieved with the help of cross fire radiation. Effects of radionuclide therapy in terms of apoptosis, cell-cycle blocks and hyperradiosensitivity are also discussed.

Place, publisher, year, edition, pages
New York: Springer , 2008. 295-310 p.
Keyword [en]
Radionuclide, Therapy, Cancer, Tumor, Radiation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104673ISBN: 978-1-4020-8695-3OAI: oai:DiVA.org:uu-104673DiVA: diva2:220043
Editors: Torgny Stigbrand, Jörgen Carlsson, Gregory P. AdamsAvailable from: 2009-05-29 Created: 2009-05-29 Last updated: 2009-06-22Bibliographically approved

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