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Targeted Radionuclide Tumor Therapy: Biological Aspects
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
Umeå University.
Fox Chase Cancer Centre.
2008 (English)Book (Other academic)
Abstract [en]

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a significant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation procedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future. The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics (dosimetry) and basic cell biology including the study of cell signalling pathways and the mechanisms of cellular death. Certainly several challenges remain in bringing targeted therapy into mainstream of treatment modalities, but in many of the chapters significant improvements in targeting efficiency are observed and may indicate future efficacy and acceptance, maybe not as a single treatment modality, but in combination with other strategies. It is the ambition of the editors to enable, with this volume, deeper insights in the process of improving targeted therapy for this diverse group of scientists. Clearly, some of the obstacles to gaining wider clinical acceptance might partly be related to this necessity of multidisciplinary collaborations. A number of disciplines, many of them mentioned above, have to both collaborate and coordinate with each other in order to control the chain of judgement necessary for the treatment of each patient. All these requirements may not always be available or easy to accomplish. This is a management paradigm shift, which usually would take some time. However, we hope that the chapters in this book will convince you, the reader, that a critical mass of knowledge regarding how to effectively use targeted radionuclide therapy has been accumulated. We believe, and hope that you will agree, that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.

Place, publisher, year, edition, pages
New York: Springer , 2008. , 402 p.
Keyword [en]
Radionuclide, Radiation, Therapy, Cancer, Tumor
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104682ISBN: 978-1-4020-8695-3OAI: oai:DiVA.org:uu-104682DiVA: diva2:220054
Available from: 2009-05-29 Created: 2009-05-29 Last updated: 2009-06-22Bibliographically approved

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