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Safety in simple versus complex stenting of coronary artery bifurcation lesions: The nordic bifurcation study 14-month follow-up results
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2008 (English)In: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, ISSN 1774-024X, Vol. 4, no 2, 229-233 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: The risk of stent thrombosis has been reported to increase with percutaneous coronary intervention (PCI) complexity. The present study reports the pre-specified secondary endpoint of a 14-month stent thrombosis and major adverse cardiac events in patients stented with a simple versus a complex bifurcation technique using sirolimus eluting stents (SES). METHODS AND RESULTS: A total of 413 patients with a coronary bifurcation lesion were randomised to a simple treatment strategy; stenting of main vessel and optional stenting of side branch (MV group), or to a complex stenting strategy; stenting of both main vessel and side branch (MV+SB group). Mortality data were available in all patients and 14-month clinical follow-up data in 395 (96%) of the patients. After 14 months, the rates of definite, probable and possible stent thrombosis (ARC criteria) were 1.0% vs. 0.5%, 1.0% vs. 0% and 0.5% vs. 0% (ns) in the MV and in the MV+SB groups, respectively. Rates of MACE were 9.5% in the MV group and 8.2% in the MV+SB group (ns). Total death was seen in 2.4% vs. 1.0% and non-PCI related myocardial infarction in 2.0% vs. 1.0% in the MV and the MV+SB groups, respectively. CONCLUSIONS: After 14 months, two months after recommended cessation of dual antiplatelet therapy, the rates of stent thrombosis and major adverse cardiac events were low and independent of treatment complexity in patients treated with SES for coronary artery bifurcation lesions.

Place, publisher, year, edition, pages
2008. Vol. 4, no 2, 229-233 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104744PubMedID: 19110788OAI: oai:DiVA.org:uu-104744DiVA: diva2:220103
Available from: 2009-05-29 Created: 2009-05-29 Last updated: 2010-07-14Bibliographically approved

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