C-peptide constricts pancreatic islet arterioles in diabetic, but not normoglycaemic mice
2008 (English)In: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 24, no 2, 165-168 p.Article in journal (Refereed) Published
BACKGROUND: Pancreatic islet blood flow is regulated separately from that of the exocrine pancreas, and a consistent finding during impaired glucose tolerance is an increased blood perfusion. The aim of the present study was to investigate whether C-peptide affects pancreatic islet arterioles in normal and diabetic mice.
MATERIALS AND METHODS: Control and diabetic C57-Bl mice were studied after 2 weeks of alloxan-induced diabetes. Islet arterioles were dissected and microperfused with Dulbecco's modified Eagle medium (DMEM) solution. The effect of luminal application of mouse C-peptide was investigated.
RESULTS: C-peptide reduced the diameter of islet arterioles from diabetic mice (-10+/-4%, P<0.05) compared to base-line values, whilst arterioles from normoglycaemic animals did not respond to C-peptide (P=0.2).
CONCLUSION: These findings suggest a role for C-peptide in the regulation of islet blood flow, especially during conditions with impaired glucose tolerance.
Place, publisher, year, edition, pages
2008. Vol. 24, no 2, 165-168 p.
diabetes, pancreas, islet arteriole, circulation, C-peptide, islet of Langerhans
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-104062DOI: 10.1002/dmrr.805ISI: 000253616200012PubMedID: 18157793OAI: oai:DiVA.org:uu-104062DiVA: diva2:220127