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C-peptide constricts pancreatic islet arterioles in diabetic, but not normoglycaemic mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi. (Nordquist)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
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2008 (English)In: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 24, no 2, 165-168 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Pancreatic islet blood flow is regulated separately from that of the exocrine pancreas, and a consistent finding during impaired glucose tolerance is an increased blood perfusion. The aim of the present study was to investigate whether C-peptide affects pancreatic islet arterioles in normal and diabetic mice.

MATERIALS AND METHODS: Control and diabetic C57-Bl mice were studied after 2 weeks of alloxan-induced diabetes. Islet arterioles were dissected and microperfused with Dulbecco's modified Eagle medium (DMEM) solution. The effect of luminal application of mouse C-peptide was investigated.

RESULTS: C-peptide reduced the diameter of islet arterioles from diabetic mice (-10+/-4%, P<0.05) compared to base-line values, whilst arterioles from normoglycaemic animals did not respond to C-peptide (P=0.2).

CONCLUSION: These findings suggest a role for C-peptide in the regulation of islet blood flow, especially during conditions with impaired glucose tolerance.

Place, publisher, year, edition, pages
2008. Vol. 24, no 2, 165-168 p.
Keyword [en]
diabetes, pancreas, islet arteriole, circulation, C-peptide, islet of Langerhans
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104062DOI: 10.1002/dmrr.805ISI: 000253616200012PubMedID: 18157793OAI: oai:DiVA.org:uu-104062DiVA: diva2:220127
Available from: 2009-05-29 Created: 2009-05-27 Last updated: 2017-12-13Bibliographically approved

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