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Genes, environment and immunity in the development of rheumatoid arthritis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
2006 (English)In: Current Opinion in Immunology, ISSN 0952-7915, E-ISSN 1879-0372, Vol. 18, no 6, 650-655 p.Article in journal (Refereed) Published
Abstract [en]

The combined role of genes, environment and immunity in the development of rheumatoid arthritis (RA) has been the subject of recent investigations. New data support a gene-environment interaction between smoking and the MHC class II HLA-DRB1 shared epitope (SE) genes in anti-citrulline antibody (anti-CP(+)) RA but not in anti-CP(-) disease. These data from genetic epidemiology, together with information on citrullination in the lungs of smokers, have prompted the formulation of a new etiological hypothesis for anti-CP(+) RA, suggesting that smoking in the context of HLA-DR SE might trigger immunity to citrulline-modified proteins and that this immunity, after several years, might cause arthritis.

Place, publisher, year, edition, pages
2006. Vol. 18, no 6, 650-655 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104785DOI: 10.1016/j.coi.2006.06.004PubMedID: 17010589OAI: oai:DiVA.org:uu-104785DiVA: diva2:220141
Available from: 2009-05-29 Created: 2009-05-29 Last updated: 2010-05-28Bibliographically approved

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