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Antikroppar mot citrullinerade proteiner - genombrott i reumatologisk diagnostik
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology. (Autoimmunitet)ORCID iD: 0000-0003-1186-3226
2004 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 101, no 50, p. 4092-4096Article, review/survey (Refereed) Published
Abstract [en]

Antibodies directed against citrullinated proteins (anti-CP) constitute a newly defined group of autoantibodies with very high diagnostic specificity for rheumatoid arthritis (RA). The most recently developed assays have a sensitivity comparable to that of traditional tests for Rheumatoid Factor (RF). Due to its considerably higher specificity, the authors recommend that anti-CP antibody analysis should replace the RF test in primary healthcare when investigating cases of clinically suspect RA.

Abstract [sv]

Antikroppar mot citrullinerade proteiner (anti-CP) ären nyligen beskriven grupp autoantikroppar medmycket hög diagnostisk specificitet för reumatoid ar-trit (RA).De senast utvecklade anti-CP-testen har en diagnos-tisk sensitivitet för RA som gör dem jämförbara medtraditionella test för reumatoid faktor.Introduktionen av anti-CP är ett viktigt tillskott till reu-matologisk laboratoriediagnostik tack vare testensbetydligt högre specificitet och prediktiva värde.Vid utredning av misstänkt RA inom primärvårdenrekommenderar vi att analys av anti-CP ersätter reu-matoid faktor som förstahandstest.

Place, publisher, year, edition, pages
2004. Vol. 101, no 50, p. 4092-4096
Keyword [sv]
ledgångsreumatism, autoantikroppar, citrullin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104791PubMedID: 15631262OAI: oai:DiVA.org:uu-104791DiVA, id: diva2:220144
Available from: 2009-05-29 Created: 2009-05-29 Last updated: 2018-02-27

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