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Targeting the insulin-regulated aminopeptidase/AT(4) receptor for cognitive disorders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2009 (English)In: Drug News and Perspectives, ISSN 0214-0934, Vol. 22, no 3, 133-139 p.Article, review/survey (Refereed) Published
Abstract [en]

The insulin-regulated aminopeptidase/AT(4) receptor has recently emerged as a new target for pharmaceutical agents aimed at treating various cognitive disorders such as Alzheimer's disease. There is an unmet need for metabolically stable drug-like angiotensin (Ang) IV analogues that exert actions mimicking the powerful memory-enhancing effects of Ang IV and LVV-hemorphin-7 and can efficiently cross the blood-brain barrier. Such new chemical entities would be attractive as research tools and would allow extensive study of the impact of Ang IV on in vivo physiology in complex animal models. Drug-like Ang IV peptidomimetics are foreseen to serve as potential lead structures for further optimization in drug discovery.

Place, publisher, year, edition, pages
2009. Vol. 22, no 3, 133-139 p.
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-104875DOI: 10.1358/dnp.2009.22.3.1325032ISI: 000266523300001PubMedID: 19440555OAI: oai:DiVA.org:uu-104875DiVA: diva2:220208
Available from: 2009-05-29 Created: 2009-05-29 Last updated: 2012-10-03Bibliographically approved

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