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The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
2005 (English)In: Ophthalmic Research, ISSN 0030-3747, E-ISSN 1423-0259, Vol. 37, no 4, 197-201 p.Article in journal (Refereed) Published
Abstract [en]

The effect of exposure time on maximum acceptable dose (MAD) for avoidance of ultraviolet radiation B (UVRB)-induced cataract was investigated. Sprague-Dawley rats were divided into 5 exposure time groups: 7.5, 15, 30, 60, and 120 min. Each exposure time group was divided into 5 dose subgroups: 0, 1, 2, 4, and 8 kJ/m2. The rats were unilaterally exposed to UVR around 300 nm. One week after the exposure, macroscopic structure was recorded and lens forward light scattering was measured. MAD for avoidance of UVRB-induced cataract was estimated based on the dose-response function. MAD for avoidance of UVRB-induced cataract for 7.5, 15, 30, 60, and 120 min exposures was estimated to be 2.0, 1.4, 1.9, 1.8 and 2.2 kJ/m2, respectively. In the exposure time domain 7.5-120 min, MAD for avoidance of UVRB-induced cataract depends on exposure time.

Place, publisher, year, edition, pages
2005. Vol. 37, no 4, 197-201 p.
Keyword [en]
maximum acceptable dose, ultraviolet radiation B, exposure time, cataract, rat, light scattering, dose-response function
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104228DOI: 10.1159/000086596ISI: 000230679700005PubMedID: 15990463OAI: oai:DiVA.org:uu-104228DiVA: diva2:220261
Available from: 2009-05-30 Created: 2009-05-28 Last updated: 2017-12-13Bibliographically approved

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