Reversal of reciprocity failure for UVR-induced cataract with vitamin E
2005 (English)In: Ophthalmic Research, ISSN 0030-3747, E-ISSN 1423-0259, Vol. 37, no 3, 150-155 p.Article in journal (Refereed) Published
PURPOSE: The authors have previously described that the photochemical reciprocity law does not apply for ultraviolet radiation (UVR)-induced cataract. The aim of this study was to elucidate if failure of the reciprocity reverses with vitamin E (alpha-tocopherol) administration. METHODS: Altogether, 80 rats were divided into one group fed alpha-tocopherol and one control group. For each group, half of rats were exposed to UVR for 5 min and the remaining rats for 15 min. RESULTS: Lenses exposed to UVR for 5 min showed no difference in light scattering between alpha-tocopherol-treated and untreated groups. Lenses exposed to UVR for 15 min showed significant difference in light scattering between alpha-tocopherol-treated and untreated groups. CONCLUSIONS: Failure in exposure time-intensity reciprocity for UVR-induced cataract with exposures shorter than 30 min may be due to consumption of antioxidants in the lens.
Place, publisher, year, edition, pages
Karger , 2005. Vol. 37, no 3, 150-155 p.
Reciprocity law, Ultraviolet radiation, Cataract, α-Tocopherol, Rats
IdentifiersURN: urn:nbn:se:uu:diva-104234DOI: 10.1159/000085850PubMedID: 15905634OAI: oai:DiVA.org:uu-104234DiVA: diva2:220267