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Repeatability in and interchangeability between the macular and the fast macular thickness map protocols: a study on normal eyes with Stratus optical coherence tomography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
2009 (English)In: Acta ophthalmologica, ISSN 1755-3768, Vol. 87, no 7, 725-730 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To collect a normal material and to compare the macular and the fast macular thickness map protocols regarding normal values and repeatability. Methods: Sixty-seven individuals underwent three repeated scans with the macular thickness protocol; 45 of them also had three scans with the fast thickness protocol in Stratus optical coherence tomography (OCT). The maps were divided into nine ETDRS fields, where thickness values were presented. The repeatability was calculated as intraclass correlation coefficient (ICC), coefficient of variance (CV) and coefficient of repeatability (CR). For comparison between the two protocols, limits of agreement were determined according to Bland-Altman. Results: Normal values for the two protocols were very close. Repeatability was high. ICC for all areas was 0.92-0.98. CV was less than 1% and CR was 6-8 mum for both protocols, with the exception of the fovea in the fast protocol (where CV was 1.44% and CR 12.4 mum). Limits of agreement between the two protocols were less than 10 mum as a rule. Conclusion: Normal values for the protocols are equal and they both have excellent repeatability. The fast macular map is a good alternative with the possible exception of the fovea, where variation is twice that of the macular thickness map.

Place, publisher, year, edition, pages
2009. Vol. 87, no 7, 725-730 p.
Keyword [en]
macular thickness maps, normal values, optical coherence tomography, repeatability
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-104911DOI: 10.1111/j.1755-3768.2008.01345.xISI: 000270999300006PubMedID: 18937816OAI: oai:DiVA.org:uu-104911DiVA: diva2:220276
Available from: 2009-05-30 Created: 2009-05-30 Last updated: 2010-09-23Bibliographically approved
In thesis
1. Aspects of Optical Coherence Tomography (OCT) in Healthy Eyes and Eyes with Retinal Diseases
Open this publication in new window or tab >>Aspects of Optical Coherence Tomography (OCT) in Healthy Eyes and Eyes with Retinal Diseases
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Optical coherence tomography (OCT) is a technique in which cross-sectional images from intraocular tissue can be obtained. The quantitative and qualitative examinations are used for evaluating retinal diseases. Conventional OCT (Stratus) is mainly used, but the new Spectral domain (Cirrus) OCT, which has improved technology, may provide more reliable measurements.

The aim of the study was to collect normal values of macular thickness in children and adults and to evaluate the effect of age and/or gender, to compare measurement variability in healthy eyes and eyes with age-related macular degeneration (AMD), to compare Stratus and Cirrus OCT and to study the effect of cataract surgery on macula.

Sixty-seven healthy adults and 56 children, 30 patients with AMD, 34 patients with diabetes and cataract and 35 healthy controls were included. The quantitative maps in Stratus and Cirrus were used and manual correction of foveal location was evaluated. Qualitative OCT was compared to fluorescein angiography (FA) after cataract surgery.

The mean values of macular thickness in Stratus OCT were 207µm in adults and 204 µm in children. The measurement variability was low. Macular thickness decreased with age in adults, but not in children. No correlation with gender was found. In eyes with wet AMD, there were small differences in measurement variability comparing Stratus and Cirrus OCT. After manual correction in Cirrus OCT, the coefficients of repeatability were improved to values close to the repeatability in normal eyes. Two thirds of the diabetic and half of the control eyes showed leakage on FA after cataract surgery. Qualitative OCT corresponded poorly to FA in diabetic eyes. A thicker macula, assessed with OCT, was often observed without any obvious effect on visual acuity.  OCT was as good as FA in revealing clinically relevant changes in macula after surgery, and was the technique recommended for follow-up.

Place, publisher, year, edition, pages
Uppsala: Acta Universitas Upsaliensis, 2010. 53 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 580
National Category
Ophthalmology
Research subject
Ophtalmology
Identifiers
urn:nbn:se:uu:diva-129163 (URN)978-91-554-7851-3 (ISBN)
Public defence
2010-09-17, Grönwallsalen, Akademiska sjukhuset, entrance 70, ground floor, 75185, Uppsala, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2010-08-27 Created: 2010-08-05 Last updated: 2012-11-20

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