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Irritable bowel syndrome and gastroesophageal reflux disease in primary care: is there a link?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
2009 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 54, no 5, 1079-1086 p.Article in journal (Refereed) Published
Abstract [en]

Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n=6,421) or IBS (n=2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3-5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7-4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.

Place, publisher, year, edition, pages
2009. Vol. 54, no 5, 1079-1086 p.
Keyword [en]
Database, epidemiology, gastroesophageal reflux, irritable bowel syndrome, primary health care
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-104947DOI: 10.1007/s10620-008-0462-0ISI: 000264810100023PubMedID: 18720002OAI: oai:DiVA.org:uu-104947DiVA: diva2:220300
Available from: 2009-05-31 Created: 2009-05-31 Last updated: 2012-06-19Bibliographically approved

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Wallander, Mari-Ann
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