uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Local recurrence in rectal cancer: anatomic localization and effect on radiation target
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Show others and affiliations
2008 (English)In: International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, Vol. 72, no 3, 658-64 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To determine the sites of local recurrence after total mesorectal excision for rectal cancer in an effort to optimize the radiation target. METHODS AND MATERIALS: A total of 155 patients with recurrence after abdominal resection for rectal cancer were identified from a population-based consecutive cohort of 2,315 patients who had undergone surgery by surgeons trained in the total mesorectal excision procedure. A total of 99 cross-sectional imaging studies were retrieved and re-examined by one radiologist. The clinical records were examined for the remaining patients. RESULTS: Evidence of residual mesorectal fat was identified in 50 of the 99 patients. In 83 patients, local recurrence was identified on the imaging studies. All recurrences were within the irradiated volume if the patients had undergone preoperative radiotherapy or within the same volume if they had not. The site of recurrence was in the lower 75% of the pelvis, anatomically below the S1-S2 interspace for all patients. Only 5 of the 44 recurrences in patients with primary tumors >5 cm from the anal verge were in the lowest 20% of the pelvis. Six recurrences involved the lateral lymph nodes. CONCLUSION: These data suggest that a lowering of the upper limit of the clinical target volume could be introduced. The anal sphincter complex with surrounding tissue could also be excluded in patients with primary tumors >5 cm from the anal verge.

Place, publisher, year, edition, pages
2008. Vol. 72, no 3, 658-64 p.
Keyword [en]
rectal cancer, radiotherapy, clinical target volume, local recurrence, total mesorectal excision
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105133DOI: 10.1016/j.ijrobp.2008.01.063ISI: 000259894300005PubMedID: 18495376OAI: oai:DiVA.org:uu-105133DiVA: diva2:220537
Available from: 2009-06-01 Created: 2009-06-01 Last updated: 2012-03-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Torkzad, Michael R.
By organisation
In the same journal
International Journal of Radiation Oncology, Biology, Physics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 171 hits
ReferencesLink to record
Permanent link

Direct link