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Chronomodulated capecitabine in combination with short-time oxaliplatin: a Nordic phase II study of second-line therapy in patients with metastatic colorectal cancer after failure to irinotecan and 5-flourouracil
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology. (Ake Berglund)
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2008 (English)In: Annals of Oncology, ISSN 0923-7534, Vol. 19, no 6, 1154-9 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Oxaliplatin in combination with capecitabine prolongs survival in patients with metastatic colorectal cancer (mCRC). Chronomodulation might reduce toxicity and improve efficacy. PATIENTS AND METHODS: A phase II study examining chronomodulated XELOX(30) (XELOX(30chron)): oxaliplatin: 130 mg/m(2) on day 1, as a 30-min infusion between 1 and 3 p.m. Capecitabine: total daily dose of 2000 mg/m(2), 20% of the dose between 7 and 9 a.m. and 80% of the dose between 6 and 8 p.m. in patients with mCRC resistant to irinotecan. Seventy-one patients were enrolled. Response rate was 18%; median progression-free survival 5.1 months and median overall survival (OS) 10.2 months. Platelet count and performance status were significantly correlated to OS in multivariate analyses. Neurotoxicity grade 2 and 3 was seen in 25% and 2% of patients, respectively, other grade 3 toxic effects were as follows: nausea 6%, vomiting 3%, diarrhoea 12% (3% experienced grade 4) and palmoplantart erytem 9%. CONCLUSION: XELOX(30chron) is a convenient second-line regimen with efficacy and safety profile similar to other oxaliplatin schedules. To further investigate chronomodulated XELOX, we have started a Nordic randomised phase II study comparing XELOX(30) and XELOX(30chron) as first-line therapy in patients with mCRC.

Place, publisher, year, edition, pages
2008. Vol. 19, no 6, 1154-9 p.
Keyword [en]
capecitabine, chronotherapy, metastatic colorectal cancer, oxaliplatin, short-time infusion, XELOX
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105354DOI: 10.1093/annonc/mdn002ISI: 000256268100017PubMedID: 18281265OAI: oai:DiVA.org:uu-105354DiVA: diva2:221142
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2009-06-09Bibliographically approved

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