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Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
2009 (English)In: The international journal of cardiovascular imaging, ISSN 1569-5794, Vol. 25, no 2, 133-40 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex. METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments. RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years. CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.

Place, publisher, year, edition, pages
2009. Vol. 25, no 2, 133-40 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-105415DOI: 10.1007/s10554-008-9366-5PubMedID: 18784986OAI: oai:DiVA.org:uu-105415DiVA: diva2:221198
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2012-03-21Bibliographically approved

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