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Fatal adenovirus infection during alemtuzumab (anti-CD52 monoclonal antibody) treatment of a patient with fludarabine-refractory B-cell chronic lymphocytic leukemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
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2002 (English)In: Medical Oncology, ISSN 1357-0560, Vol. 19, no 4, 277-80 p.Article in journal (Refereed) Published
Abstract [en]

Alemtuzumab (Campath-1H) is a humanized CD52 monoclonal antibody that targets normal as well as malignant B- and T-lymphocytes. Alemtuzumab has significant antitumor activity in chronic lymphocytic leukemia (B-CLL) but also induces immunosuppression. We describe a case of fatal adenovirus infection in a heavily pretreated patient with fludarabine-refractory B-CLL receiving alemtuzumab therapy, drawing attention to the fact that also viruses other than cytomegalovirus (CMV) and herpes simplex (HSV) need to be considered in B-CLL patients with fever of unknown origin while on alemtuzumab treatment.

Place, publisher, year, edition, pages
2002. Vol. 19, no 4, 277-80 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-105422DOI: 10.1385/MO:19:4:277PubMedID: 12512923OAI: oai:DiVA.org:uu-105422DiVA: diva2:221202
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2009-06-09Bibliographically approved

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