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Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
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2008 (English)In: British Journal of Cancer, ISSN 0007-0920, Vol. 98, no 5, 1001-1005 p.Article in journal (Refereed) Published
Abstract [en]

This study estimated the risk of second primary malignancies after Hodgkin's lymphoma (HL) in relation to family history of cancer, age at diagnosis and latency, among 6946 patients treated for HL in Sweden in 1965-1995 identified through the Swedish Cancer Register (SCR). First-degree relatives (FDRs) to the HL patients and their malignancies were then ascertained together with their malignancies through the Multi-Generation Registry and SCR. The HL patient cohort was stratified on the number of FDRs with cancer, and standardised incidence ratios (SIRs) of developing SM were analysed. In the HL cohort, 781 SM were observed 1 year or longer after HL diagnosis. The risk for developing SM increased with the number of FDRs with cancer, SIRs being 2.26, 3.01, and 3.45 with 0, 1, or >or=2 FDRs with cancer, respectively. Hodgkin's lymphoma long-term survivors treated at a young age with a family history of cancer carry an increased risk for developing SM and may represent a subgroup where standardised screening for the most common cancer sites could be offered in a stringent surveillance programme.

Place, publisher, year, edition, pages
2008. Vol. 98, no 5, 1001-1005 p.
Keyword [en]
late effect, radiotherapy, second malignancy, cohort
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105431DOI: 10.1038/sj.bjc.6604244ISI: 000254529000022PubMedID: 18268493OAI: oai:DiVA.org:uu-105431DiVA: diva2:221213
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2009-11-12Bibliographically approved

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