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Inflammatory cells and immune microenvironment in malignant lymphoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
2008 (English)In: Journal of Internal Medicine, ISSN 0954-6820, Vol. 264, no 6, 528-36 p.Article in journal (Refereed) Published
Abstract [en]

It has become clear that the biological and clinical behaviour of malignant lymphoma is not only determined by the properties of the tumour cells themselves but are also largely by the interaction of the tumour cells with their nonmalignant microenvironment. The composition and functional status of the tumour microenvironment is highly variable between different classes of malignant lymphoma and may provide both growth-supportive and growth suppressive signals via components of the adaptive and innate immune response. In this review, the functional interactions and clinical consequences of these insights are discussed in indolent and aggressive B-cell lymphomas and in classical Hodgkin's lymphoma.

Place, publisher, year, edition, pages
2008. Vol. 264, no 6, 528-36 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105432DOI: 10.1111/j.1365-2796.2008.02032.xPubMedID: 19017177OAI: oai:DiVA.org:uu-105432DiVA: diva2:221214
Available from: 2009-06-03 Created: 2009-06-03 Last updated: 2009-09-09Bibliographically approved

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