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Arsenic is decreased in target organs during viral infection in mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Infektionssjukdomar)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Enheten för metallbiologisk forskning.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Enheten för metallbiologisk forskning.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Infektionssjukdomar)
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2006 (English)In: Journal of Trace Elements in Medicine and Biology, ISSN 0946-672X, E-ISSN 1878-3252, Vol. 20, no 2, 121-126 p.Article in journal (Refereed) Published
Abstract [en]

Arsenic (As), a potentially toxic trace element, has been shown to influence viral replication and resistance to microbial infection. However, the impact of infection on the normal As status in target organs involved in the disease process has not been studied to date. In the present study, As was measured through inductively coupled plasma mass spectrometry in the plasma, liver, spleen, kidney, heart, pancreas and brain at days 1 and 3 of coxsackievirus B3 infection in female Balb/c mice. The severity of the infection was assessed from clinical signs of disease. The infection changed plasma As in a biphasic pattern with a small increase (n.s.) at day 1 that turned into a decreasing trend (13%, p<0.05) by day 3. In the liver, spleen, heart, pancreas and kidney As was unchanged at day 1 but, at day 3, it had decreased by 71% (p<0.01), 64% (p<0.01), 55% (p<0.01), 63% (p<0.01) and 73% (p<0.01), respectively. In the brain, As went unchanged. The pathophysiological interpretation of these findings requires further research.

Place, publisher, year, edition, pages
2006. Vol. 20, no 2, 121-126 p.
Keyword [en]
Arsenic, Organ, Virus
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-105469DOI: 10.1016/j.jtemb.2005.12.002PubMedID: 16785052 OAI: oai:DiVA.org:uu-105469DiVA: diva2:221345
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2017-12-13Bibliographically approved

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Department of Medical SciencesDepartment of Oncology, Radiology and Clinical ImmunologyEnheten för metallbiologisk forskning
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Journal of Trace Elements in Medicine and Biology
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