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High cyclin B1 expression is associated with poor survival in breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2009 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 100, no 7, 1055-60 p.Article in journal (Refereed) Published
Abstract [en]

Cyclin B1 regulates the G(2)-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological variables and prognostic role in breast cancer are not fully understood. Traditionally used prognostic criteria identify large subset of patients to receive adjuvant chemotherapy and to be exposed to adverse effects. A reliable and simple method helping prognostic evaluation in breast cancer is needed. We analysed cyclin B1 expression on 1348 invasive breast cancers and studied correlations with other histopathological variables and survival. High cyclin B1 correlated with high tumour grade, large tumour size and positive nodal status, oestrogen and progesterone receptor negativity, positive HER2 and p53 status, young age at diagnosis, and high cyclin E, cyclin A and Ki67 expression. Among patients not given adjuvant chemotherapy high cyclin B1 was a strong predictor of shorter overall and metastasis-free survival (RR 3.74, P<0.0005 and RR 3.51, P<0.0005, respectively), and remained as an independent prognostic factor also in multivariate analysis (RR 1.80, P=0.04 and RR 2.31, P=0.02, respectively). This study suggests high cyclin B1 associates with aggressive phenotype and is an independent prognostic factor in breast cancer.

Place, publisher, year, edition, pages
2009. Vol. 100, no 7, 1055-60 p.
Keyword [en]
breast cancer, cyclin B1, survival, prognosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105531DOI: 10.1038/sj.bjc.6604874ISI: 000264747700007PubMedID: 19293801OAI: oai:DiVA.org:uu-105531DiVA: diva2:221442
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2012-03-15Bibliographically approved

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