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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
Dept. of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden.
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2008 (English)In: Acta Diabetologica, ISSN 0940-5429, Vol. 45, no 4, 231-5 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.

Place, publisher, year, edition, pages
2008. Vol. 45, no 4, 231-5 p.
Keyword [en]
HLA-DQ, Genotype, Temporal trends, Age at diagnosis, Autoimmune disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-105693DOI: 10.1007/s00592-008-0048-5PubMedID: 18769865OAI: oai:DiVA.org:uu-105693DiVA: diva2:222271
Available from: 2009-06-08 Created: 2009-06-08 Last updated: 2009-07-27Bibliographically approved

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