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Horizontal gene transfer between microbial eukaryotes.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organism Biology, Molecular Evolution.
2009 (English)In: Methods in Molecular Biology, ISSN 1064-3745, Vol. 532, no 4, 473-487 p.Article in journal (Refereed) Published
Abstract [en]

Comparative genomics have identified two loosely defined classes of genes: widely distributed core genes that encode proteins for central functions in the cell and accessory genes that are patchily distributed across lineages and encode taxa-specific functions. Studies of microbial eukaryotes show that both categories undergo horizontal gene transfer (HGT) from prokaryotes, but also between eukaryotic organisms. Intra-domain gene transfers of most core genes seem to be relatively infrequent and therefore comparatively easy to detect using phylogenetic methods. In contrast, phylogenies of accessory genes often have complex topologies with little or no resemblance of organismal relationships typically with eukaryotes and prokaryotes intermingled, making detailed evolutionary histories difficult to interpret. Nevertheless, this suggests significant rates of gene transfer between and among the three domains of life for many of these genes, affecting a considerably diversity of eukaryotic microbes, although the current depth of taxonomic sampling usually is insufficient to pin down individual transfer events. The occurrence of intra-domain transfer among microbial eukaryotes has important implications for studies of organismal phylogeny as well as eukaryote genome evolution in general.

Place, publisher, year, edition, pages
2009. Vol. 532, no 4, 473-487 p.
National Category
Biological Sciences
Research subject
Molecular Biology
URN: urn:nbn:se:uu:diva-105975DOI: 10.1007/978-1-60327-853-9_27PubMedID: 19271202OAI: oai:DiVA.org:uu-105975DiVA: diva2:223052
Available from: 2009-06-10 Created: 2009-06-10 Last updated: 2011-02-15Bibliographically approved

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