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Case-controlled structure validation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Molecular Biology.
2009 (English)In: Acta Crystallographica Section D: Biological Crystallography, ISSN 0907-4449, E-ISSN 1399-0047, Vol. 65, no Pt 2, 140-147 p.Article in journal (Refereed) Published
Abstract [en]

Although many factors influence the quality of a macromolecular crystal structure, validation criteria are usually only calibrated using one of these factors, the resolution. For many purposes this is sufficient, but there are times when one wishes to compare one set of structures with another and the comparison may be invalidated by systematic differences between the sets in factors other than resolution. This problem can be circumvented by borrowing from medicine the idea of the case-matched control: each structure of interest is matched with a control structure that has similar values for all relevant factors considered in this study. In addition to resolution, these include the size of the structure (as measured by the volume of the asymmetric unit) and the year of deposition. This approach has been applied to address two questions: whether structures from structural genomics efforts reach the same level of quality as structures from traditional sources and whether the impact factor of the journal in which a structure is published correlates with structure quality. In both cases, once factors influencing quality have been controlled in the comparison, there is little evidence for a systematic difference in quality.

Place, publisher, year, edition, pages
2009. Vol. 65, no Pt 2, 140-147 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-105995DOI: 10.1107/S0907444908041085ISI: 000263557900006PubMedID: 19171969OAI: oai:DiVA.org:uu-105995DiVA: diva2:223147
Available from: 2009-06-11 Created: 2009-06-11 Last updated: 2017-12-13Bibliographically approved

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