Design and synthesis of glycosylated b 3-peptides capable of folding into the 314-helical conformation in water
2008 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, Vol. 73, no 14, 5272-5278 p.Article in journal (Refereed) Published
Herein, we describe the synthesis of seven glycosylated adopt stable 3 novel class of functionalized foldamers in which a natural post-translational modification is attached to an unnatural peptidomimetic backbone. Conformational studies by CD spectroscopic measurements were performed in methanol and in water (pH 7). Additionally, the influence of temperature, pH, and concentration on the ability of glycosylated were investigated. The first NMR-derived solution state structure of a glycosylated water is also presented.
Place, publisher, year, edition, pages
2008. Vol. 73, no 14, 5272-5278 p.
IdentifiersURN: urn:nbn:se:uu:diva-106040DOI: 10.1021/jo8003265ISI: 000257543100009OAI: oai:DiVA.org:uu-106040DiVA: diva2:223513