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Obstructive sleep apnoea is associated with decreased insulin sensitivity in females
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Diabetes och endokrinologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2008 (English)In: European Respiratory Journal, ISSN 0903-1936, Vol. 31, no 5, 1054-60 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to assess associations between obstructive sleep apnoea and insulin sensitivity in a population-based sample of females. In total, 400 females aged 20-70 yrs underwent a full-night polysomnography, fasting blood sampling, measurement of anthropometric variables and oral glucose tolerance test with measurement of the insulin response (n = 358). The apnoea/hypopnoea index (AHI) was calculated from the results of the polysomnography. From the results of the oral glucose tolerance test, an insulin sensitivity index (ISI) was calculated. Females with an AHI < 5 (n = 119) had a mean+/-SD ISI of 8.3+/-3.8, whereas females with an AHI > or = 30 (n = 34) had an ISI of 6.2+/-4.0. Nocturnal minimal saturation was independently associated with decreased insulin sensitivity when controlling for age, waist/hip ratio, level of physical activity, smoking and alcohol consumption (95% confidence interval (CI) 0.004-0.14). When adjusting for confounders, the AHI was associated with increased fasting and 2-h insulin levels (95% CI 0.14-0.99 and 95% CI 0.28-6.47, respectively). Obstructive sleep apnoea was found to be independently associated with decreased insulin sensitivity in the present population-based sample of females.

Place, publisher, year, edition, pages
2008. Vol. 31, no 5, 1054-60 p.
Keyword [en]
Females, glucose metabolism, insulin sensitivity, population-based, sleep-disordered breathing
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-106227DOI: 10.1183/09031936.00074907ISI: 000255707000024PubMedID: 18184681OAI: oai:DiVA.org:uu-106227DiVA: diva2:224273
Available from: 2009-06-17 Created: 2009-06-17 Last updated: 2009-11-04Bibliographically approved

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