F(2)-isoprostanes, tocopherols and normal pregnancy
2009 (English)In: Free radical research, ISSN 1071-5762, Vol. 43, no 6, 546-552 p.Article in journal (Refereed) Published
This study investigates oxidative stress and antioxidants in normal human pregnancy and post-partum period. Thirty-seven healthy women with normal pregnancies were included. Both urinary and serum samples were collected throughout the pregnancy and post-partum period. Oxidative stress was estimated by measuring the reliable in vivo marker, namely 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha,) an F(2)-isoprostane) and antioxidant status was evaluated by measuring alpha- and gamma-tocopherol in serum samples. Pregnancy was associated with successively increased levels of 8-iso-PGF(2alpha) with advancing gestational age. The median post-partum value corresponded to the values observed in early gestation and a significant decrease was observed from late pregnancy to the post-partum period. Lipid-adjusted alpha- and gamma-tocopherol levels decreased with advancing gestational age. This longitudinal study suggests that mild oxidative stress is involved in normal human pregnancy.
Place, publisher, year, edition, pages
2009. Vol. 43, no 6, 546-552 p.
Pregnancy, free radicals, oxidative stress, antioxidants, isoprostanes, human
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-106311DOI: 10.1080/10715760902902737ISI: 000266979100004PubMedID: 19384749OAI: oai:DiVA.org:uu-106311DiVA: diva2:224500