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The legacy of domestication: Accumulation of deleterious mutations in the dog genome
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Evolutionary Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2008 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 25, no 11, 2331-2336 p.Article in journal (Refereed) Published
Abstract [en]

Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf. We compared variation in dog and wolf genes using whole-genome single nucleotide polymorphism (SNP) data. The d(N)/d(S) ratio (omega) was around 50% greater for SNPs found in dogs than in wolves, indicating that a higher proportion of nonsynonymous alleles segregate in dogs compared with nonfunctional genetic variation. We suggest that the majority of these alleles are slightly deleterious and that two main factors may have contributed to their increase. The first is a relaxation of selective constraint due to a population bottleneck and altered breeding patterns accompanying domestication. The second is a reduction of effective population size at loci linked to those under positive selection due to Hill-Robertson interference. An increase in slightly deleterious genetic variation could contribute to the prevalence of disease in modern dog breeds.

Place, publisher, year, edition, pages
2008. Vol. 25, no 11, 2331-2336 p.
Keyword [en]
genetic drift, bottleneck, selective constraint, purifying selection, domestication, dog genome
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-106449DOI: 10.1093/molbev/msn177ISI: 000260152700010OAI: oai:DiVA.org:uu-106449DiVA: diva2:224940
Available from: 2009-06-23 Created: 2009-06-23 Last updated: 2011-06-28Bibliographically approved

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Webster, Matthew T.
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