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Glucagon stimulation test for estimating endogenous insulin secretion in dogs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Autoimmuna sjukdomar (Kämpe))
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2008 (English)In: The Veterinary Record, ISSN 0042-4900, Vol. 163, no 9, 266-270 p.Article in journal (Refereed) Published
Abstract [en]

Fifty-one dogs (27 diabetic dogs, four that had recovered from diabetes and 20 healthy control dogs) were given 0.5 or 1.0 mg glucagon intravenously. Blood samples were taken before the injection and 10 and 20 minutes after it. Samples were analysed to determine C-peptide, insulin and glucose concentrations, and one sample from each dog was analysed for fructosamine. The median (interquartile range) concentrations of C-peptide in the samples taken at 10 minutes were 0.5 (0.3 to 0.8) nmol/l in the control dogs, 0.1 (0 to 0.2) nmol/l in the diabetic dogs, and 0.3 (0.2 to 0.4) nmol/l in the dogs that had recovered from diabetes. Seven of the 51 dogs showed mild adverse reactions after the injection of glucagon.

Place, publisher, year, edition, pages
2008. Vol. 163, no 9, 266-270 p.
National Category
Veterinary Science
URN: urn:nbn:se:uu:diva-106865ISI: 000259301900009PubMedID: 18757903OAI: oai:DiVA.org:uu-106865DiVA: diva2:227020
Available from: 2009-07-08 Created: 2009-07-07 Last updated: 2011-03-17Bibliographically approved

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