Access to chiral tertiary amines via the iridium-catalyzed asymmetric hydrogenation of enamines
2008 (English)In: Tetrahedron Letters, ISSN 0040-4039, Vol. 49, no 51, 7290-7293 p.Article in journal (Refereed) Published
The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee.
Place, publisher, year, edition, pages
2008. Vol. 49, no 51, 7290-7293 p.
Asymmetric catalysis, Hydrogenation, Enamines, Chiral tertiary amines
IdentifiersURN: urn:nbn:se:uu:diva-106984DOI: 10.1016/j.tetlet.2008.10.035ISI: 000261532000015OAI: oai:DiVA.org:uu-106984DiVA: diva2:227527