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Lung cancer susceptibility locus at 5p15.33
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2008 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 40, no 12, 1404-1406 p.Article in journal (Refereed) Published
Abstract [en]

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P - 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

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2008. Vol. 40, no 12, 1404-1406 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-107024DOI: 10.1038/ng.254ISI: 000261215900014OAI: oai:DiVA.org:uu-107024DiVA: diva2:227575
Available from: 2009-07-15 Created: 2009-07-15 Last updated: 2017-12-13Bibliographically approved

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