Menstrual cycle length is an age-independent marker of female fertility: results from 6271 treatment cycles of in vitro fertilization
2008 (English)In: Fertility and Sterility, ISSN 0015-0282, Vol. 90, no 5, 1656-1661 p.Article in journal (Refereed) Published
OBJECTIVE: To investigate whether menstrual cycle length correlates with success rates at IVF/intracytoplasmic sperm injection (ICSI) and could be used as a marker of ovarian reserve. DESIGN: Prospective observational study. SETTING: Private infertility centre. PATIENT(S): A total of 6271 IVF/ICSI treatment cycles. INTERVENTION(S): Self-reported mean number of menstrual days during the last year was recorded before initiation of IVF/ICSI treatment. MAIN OUTCOME MEASURE(S): Relations between menstrual cycle length and pregnancy and delivery rates. RESULT(S): Increasing age was associated with a subtle shortening of mean menstrual cycle length. Menstrual cycle length correlated linearly with pregnancy and delivery rates, even after age adjustment. The chance of delivery after IVF/ICSI was almost doubled for women with a menstrual cycle length >34 days compared with women with a menstrual cycle length <26 days. Menstrual cycle length was also significantly associated with ovarian response to FSH/hMG stimulation and embryo quality. CONCLUSION(S): Mean menstrual cycle length is highly related to success rates in assisted reproduction, independently of age. A precise menstrual cycle history could be used as a simple marker of ovarian reserve.
Place, publisher, year, edition, pages
2008. Vol. 90, no 5, 1656-1661 p.
Fecundity, female age, infertility, IVF, menstrual cycle, ovarian reserve
IdentifiersURN: urn:nbn:se:uu:diva-107097DOI: 10.1016/j.fertnstert.2007.09.036ISI: 000260752000015PubMedID: 18155201OAI: oai:DiVA.org:uu-107097DiVA: diva2:227658