Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats
2009 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 467, no 3, 189-193 p.Article in journal (Refereed) Published
The misuse of anabolic androgenic steroids has in several reports been associated with effects resulting in altered behavior and cognition. This study used the Morris water maze task to investigate the effect of high doses of the anabolic androgenic steroid nandrolone on spatial learning and memory in male rats. The results on day two of the experiment and during the final probe trial indicated significant memory impairment compared with controls. The hippocampus, a brain region associated with cognitive function, was analyzed for mRNA expression of prodynorphin, the precursor of dynorphinergic peptides. The results indicated that the transcription levels of prodynorphin were significantly elevated in the animals treated with nandrolone compared with controls. Thus, the findings suggest that administration of nandrolone to male rats impairs memory function, possibly via dynorphinergic actions.
Place, publisher, year, edition, pages
2009. Vol. 467, no 3, 189-193 p.
Anabolic androgenic steroids (AAS), Learning and memory, Morris water maze, Rat, Prodynorphin, TaqMan PCR
Research subject Biological Research on Drug Dependence
IdentifiersURN: urn:nbn:se:uu:diva-107477DOI: 10.1016/j.neulet.2009.09.041ISI: 000272517600002PubMedID: 19782718OAI: oai:DiVA.org:uu-107477DiVA: diva2:231405