uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Virus population dynamics and acquired virus resistance in natural microbial communities.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution, Limnology.
2008 (English)In: Science, ISSN 0036-8075, Vol. 320, no 5879, 1047-1050 p.Article in journal (Refereed) Published
Abstract [en]

Viruses shape microbial community structure and function by altering the fitness of their hosts and by promoting genetic exchange. The complexity of most natural ecosystems has precluded detailed studies of virus-host interactions. We reconstructed virus and host bacterial and archaeal genome sequences from community genomic data from two natural acidophilic biofilms. Viruses were matched to their hosts by analyzing spacer sequences that occur among clustered regularly interspaced short palindromic repeats (CRISPRs) that are a hallmark of virus resistance. Virus population genomic analyses provided evidence that extensive recombination shuffles sequence motifs sufficiently to evade CRISPR spacers. Only the most recently acquired spacers match coexisting viruses, which suggests that community stability is achieved by rapid but compensatory shifts in host resistance levels and virus population structure.

Place, publisher, year, edition, pages
2008. Vol. 320, no 5879, 1047-1050 p.
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-107651DOI: 10.1126/science.1157358OAI: oai:DiVA.org:uu-107651DiVA: diva2:232342
Available from: 2009-08-21 Created: 2009-08-21 Last updated: 2010-01-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full texthttp://www.sciencemag.org/cgi/content/abstract/320/5879/1047
By organisation
In the same journal
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 173 hits
ReferencesLink to record
Permanent link

Direct link