Correlation of in vitro dissolution rate and apparent solubility in buffered media using a miniaturized rotating disk equipment: Part I. Comparison with a traditional USP rotating disk apparatus
2009 (English)In: Drug Discoveries & Therapeutics, ISSN 1881-7831, Vol. 3, no 3, 104-113 p.Article in journal (Refereed) Published
A correlation of the logarithmic values of the in vitro dissolution rate, G, and the apparent solubility, S, was evaluated in phosphate and ammonium acetate buffer at an initial pH of 7. The dissolution rates were determined with a newly designed and build miniaturized rotating disk equipment, as well as with a traditional rotating disk apparatus. The two apparatuses gave the same correlation pattern of logG and logS. Thirteen diverse drug substances from all of the classes in the Biopharmaceutics Classification System (BCS) were used for the correlation in the phosphate buffer system, with the results from the miniaturized apparatus only. A coefficient of determination, R2, of 0.982 was found if bases formulated as hydrochloride salts were excluded in the correlation. The miniaturized equipment is used for rapid screening of the dissolution rate, approximately 10 min for one run, and consumes small amounts of substance (about 5 mg) and dissolution media. All quantifications were performed by using reversed phase high-performance liquid chromatography (RPHPLC) with a diode array detector (DAD), integrated with the miniaturized rotating disk equipment.
Place, publisher, year, edition, pages
IACMHR and SDU-DDSC , 2009. Vol. 3, no 3, 104-113 p.
dissolution rate, solubility, in vitro models, correlation, HPLC (high-performance liquid chromatography)
Research subject Analytical Pharmaceutical Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-107740OAI: oai:DiVA.org:uu-107740DiVA: diva2:232681