Evolution of Host Adaptation Systems in the Mammalian Blood Specialist Bartonella
(English)Manuscript (preprint) (Other academic)
Bacteria of the genus Bartonella are facultative intracellular bacteria infecting the red blood cells of mammals. Bartonella isolates have now been reported from a wide range of mammalian host species, including humans, domestic animals such as pets and livestock, as well as many wild animals such as deer, moose, kangaroo, and whales. Here, we present the first major genus-wide investigation of host-adaptation systems in Bartonella, using 5 published and 5 draft genome sequences. The sampling includes both clinical and natural isolates, and represent well the major phylogenetic diversity of the genus. Our study reveals four distinct protein families of Type V Secretion Systems (T5SS) shared by all sequenced members of the genus. We also show that a recently identified gene transfer agent (GTA) consisting of a defective phage is, surprisingly, the most conserved gene cluster among all Bartonella-specific or imported genes, strongly emphasizing the functional importance of this system for the life-style and evolution of Bartonella.
host adaptation, pathogen, secretion systems, flagella, gene transfer agent, evolution
Bioinformatics and Systems Biology
Research subject Evolutionary Genetics
IdentifiersURN: urn:nbn:se:uu:diva-107784OAI: oai:DiVA.org:uu-107784DiVA: diva2:232918