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Low levels of IgM antibodies against phosphorylcholine: a potential risk marker for ischemic stroke in men
Dept of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
Dept of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Allmänpediatrisk forskning/Nordvall)
Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Sweden.
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2009 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 203, no 2, 528-532 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD). METHODS: We studied 349 incident cases (200 men) of first events of CVD (coronary heart disease (CHD; n=203 or ischemic stroke; n=146) and 693 age- and sex-matched controls identified through 12 years of follow-up (1991-2003) of subjects from the cardiovascular cohort within the Malmö Diet and Cancer Study. Relative risks (RR) of CVD with 95% confidence intervals (CI) of incident CVD with adjustments for age, smoking, total cholesterol and blood pressure were determined. Anti-PC-levels were measured using ELISA (Athera CVDefine). RESULTS: As determined using Athera CVDefine, significant associations were attained with values of anti-PC below 17U/ml (corresponding to the lowest 9th percentile), which remained after taking confounders into account (RR: 1.79, 95% CI: 1.09-2.94, p=0.021). If men were studied separately, significance was evident at values below 17U/ml (RR: 2.01, 95% CI: 1.11-3.67, p=0.022), which was not the case among women. Furthermore, values below 17U/ml were also associated with ischemic stroke (RR=3.67, 95% CI: 1.34-10.1, p=0.01), but not with CHD. CONCLUSION: Low IgM anti-PC could be a novel risk marker for development of ischemic stroke in men. Further studies are needed to establish gender and subgroup differences.

Place, publisher, year, edition, pages
2009. Vol. 203, no 2, 528-532 p.
Keyword [en]
Cardiovascular disease, Antibodies, Phosphorylcholine, Immune system, Risk marker
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-107817DOI: 10.1016/j.atherosclerosis.2008.07.009ISI: 000265464800031PubMedID: 18809177OAI: oai:DiVA.org:uu-107817DiVA: diva2:233240
Available from: 2009-08-31 Created: 2009-08-31 Last updated: 2010-07-30Bibliographically approved

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